A Simple Method for the Alkylation of Diethyl Malonate
نویسندگان
چکیده
Alkylmalonic esters, which have been recognized as important intermediates in the syntheses of various carboxylic acids, amino acids, etc., can be obtained by a variety of methods.1) Excepting the introduction of tertiary alkyl groups, the alkylation of malonic esters with alkyl halides in basic conditions, for example, in ethanol in the presence of sodium ethoxide, is one of the most important and popular methods. In this paper, we wish to report a simple and facile method for the alkylation of diethyl malonate. In connection with other work2), it was observed that diethyl malonate reacted with methyl iodide in N, N-dimethylformamide (DMF) solution in the
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